From: Lynn McIntosh [faiml@uswest.net] Sent: Wednesday, February 02, 2000 3:33 AM To: FAIMLanon; FAIML Cc: faiml@miamiferret.org Subject: FAIML #382; February 2, 2000 Ferret Adrenal/Insulinoma Mailing List (FAIML) #382; February 2, 2000 1. Farley 2. hello I'm new 3. melatonin for how long? 4. Replies and a diet question 5. drinking pee 6. Butterfly needles 7. Re: FAIML #381; Jan. 30, 2000 (Weight Loss-Patch) 8. Re: FAIML #381; Jan. 30, 2000 (surgery for five-year-old) 9. adrenal surgery for 5 year old 10. pediapred vs. prednisone 11. Questions on Lupron 12. Mitotane 13. Several replies 14. Addition to previous post... 15. BIG's middle name for sale The FERRET ADRENAL/INSULINOMA MAILING LIST (FAIML) is a group that's come together to share support and information about adrenal and insulinoma diseases. FAIML comes out in digest format three to six times per week, depending on the number of posts sent, and their surgency. FAIML information is the opinion, only, of subscribers, mostly ferret caretakers. It is not medical advice, comes with no guarantee of accuracy, and is not meant to replace the examination and medical oversight of a qualified veterinarian. If your ferret is sick or exhibiting signs of illness take your fur kid to the most ferret- experienced vet you can find! A ferret- experienced vet is one of the most important services you can provide to your ferret. TO POST: Write POST at the end of your subject heading (the more specific you can be in your subject heading, the better) and send to . URGENT POSTS: If you feel the message is urgent please mark it POST URGENT and I'll send it out to subscribers as soon as I can, then include the message in the next list. CALIFORNIA RESIDENTS: Please write POST ANONYMOUS after your subject heading if you don't want your address or last name published. SUBSCRIBE/UNSUBSCRIBE: Just use the one address for posts, subscription questions, requests, cancellations, comments, etc. The list is run by hand so just send me an email. ADRENAL/INSULINOMA WEBSITE: FAIML ARCHIVES/PHOTOS: Past FAIMLs are being archived, with a search feature, on Michael Janke's adrenal/insulinoma web site: . Michael is also kindly posting pictures of FAIML subscribers and the ferrets at this site in the FAIML Album. Check out his site for more info. PAM GREENE's FERRET FAQs: I suggest people read (and reread) Pamela Greene's Disease FAQ's on Insulin and Adrenal diseases, as they offer a good background. I forward them to all new subscribers, and will gladly send them upon request. I also send the "Disease Package", a file that tells how to get all six of Pamela Greene's FAQs on ferret diseases. Pam also has excellent FAQ's about general ferret care as well, and a link to these may be found on the FERRET CENTRAL web site: . THE FERRET MAILING LIST (FML): The FML has 3,000+ ferret-loving subscribers and the topic is simply ferrets, ferrets, and more ferrets. Moderated by Mr. Bill Gruber, it's a great source of ferret entertainment and information. Visit FERRET CENTRAL on the web (see paragraph above) for more info on the FML. To subscribe to the FML, send email to its moderator, Bill Gruber, at and ask to be added. You can also try subscribing automatically by sending email to with the command SUBSCRIBE FERRET in the body of the email. 1. Farley From: Gayle Ritzert Date sent: Tue, 1 Feb 2000 10:55:21 -0500 Thank you all for the letters of encouragement. I feel so much better. Farley is scheduled for surgery on February 11. He will continue his antibiotics until surgery for his prostate problems. My veterinarian recommended about 1 inch of Laxatone every other day to prevent hairballs, Farley also had small blood blisters between his shoulders. My veterinarian said they were self-inflicted from scratching due to itchiness, another sign of adrenal disease. Gayle 2. hello I'm new From: Martha Sprague Date sent: Tue, 1 Feb 2000 16:49:04 -0800 (PST) Hi everyone. I just joined this list today & am really hoping to learn a lot. I have 2 ferrets--Spaz & Taz. Spaz was diagnosed with insulinoma this December, but has been showing signs since last August (we had an twit for a vet that said he's diabetic & to feed him as much sugar as we could every day). At Christmas we went back home (Texas) & took him to his usual vet & she diagnosed insulinoma & put him on pediapred. We recently moved to Oklahoma & have been going nuts trying to find a good ferret vet. We finally found one last week about an hour away & are thrilled! I wanted to ask if anyone knew of a good ferret vet in Oklahoma or Southern Kansas? We want to know more than one in case we have to get a second opinion. Spaz is doing better--gaining weight and his glucose has gone up to 68 (54 in December). He's on duck soup (Gerber chicken, a/d, mushed ferret food, brewers yeast, and enzymes)--what do you guys think? I'm undecided about the enzymes. He won't eat on his own, but the pediapred sure has helped his appetite! The new vet is hoping to get his glucose up to the low 80's and do surgery on him (take part of the pancreas out). Is this what is generally done (he's 5.5 years old)? I'm trying to learn as much as I can as fast as I can, know what I mean? Thanks in advance, Martha, Spaz & Taz 3. melatonin for how long? From: "Adrienne Doucette" Date sent: Mon, 31 Jan 2000 10:05:37 EST Hi everyone, I have a 5 1/2 year old female who started showing signs of adrenal disease when she was 2 1/2 years old. For many reasons we didn't operate but instead treated her with lysodren. She responded fairly well over the years, she even went in to remission this past spring for a few months. Her major symptoms were the hair loss, swollen vulva and aggressiveness towards others. Now shes almost completley bald and about a month ago I started her on melatonin (1Mg) daily. She started growing hair in about three weeks...A truly amazing sight after you seen your ferret go totally bald. Any way what I don't know is how long do I keep her on the melatonin, Is this going to be daily for life or is it a seasonal thing. Any additional info will be helpful, Thanks for any info Adrienne 4. Replies and a diet question From: Christine Bertch Date sent: Sat, 29 Jan 2000 22:46:19 -0800 First, I agree with giving Ferretone instead of Ferretvite with the pred--it's much less sugary. I even tried giving my Missy pred in Ferretone. She almost went for it, but pred doesn't mix very well so she just has to have her treat after her pred. With my insulinoma boy Benji, I just put it in his food (duck soup) and he doesn't know the difference. Regarding the loss of a cagemate, I think it depends on the ferret. When Benji lost his friend Rikki, he looked around for her but I brought someone new in quickly so it didn't seem like he dwelled on it. If you can't find another ferret to keep his mind off of his lost friend, then I, too, think it's very important just to give them lots of love and attention. Now I have one question. Benji has been diagnosed with insulinoma for about six months now and he's on .3cc's of pred 2x daily. He only eats his special soup so he has gained a little too much weight. Should I try to decrease his feedings any or change the soup? I currently feed him 30cc's 4x daily. The soup is a mix of a/d (probably the most calories--the one I may want to cut back on), canned feline development, canned 8-1 ferret food, chicken baby food, a small amount of Nutri-Cal, Brewer's Yeast, and water. I'm guessing that (in trying to make sure he is getting all the nutrients he needs) I am just putting too many calories in. Any suggestions would be greatly appreciated! Christine, Benjamin, and Missy 5. drinking pee From: "Debbie Magerr" Date sent: Mon, 31 Jan 2000 16:28:33 -0800 I remember reading about ferrets drinking their pee, but I don't remember what the replies were. I noticed Sid doing this alot lately. Should I be concerned? He went to the vet awhile ago because he limps, xrays showed a very large spleen, but everything else seemed ok (heart, glucose etc..) ps. when Sid lost his cagemate, I just gave him x-tra attention & he seemed to do fine. My thoughts to all who lost their fuzzies! sooo sad they have all these terrible problems! Debbie & Sid (missing Punky & Nancy) 6. Butterfly needles From: Linda.Doran@att.net Date sent: Wed, 02 Feb 2000 01:57:50 +0000 Does anyone here know where I may order butterfly needles for sub-Q fluid injection in ferrets? My vet charged me $1 each for 10 of these needles today -- that seems excessive to me. Is that a normal cost for these? 7. Re: FAIML #381; Jan. 30, 2000 (Weight Loss- Patch) From: WGHOL@aol.com Date sent: Mon, 31 Jan 2000 18:25:08 EST In a message dated 1/30/00 8:47:54 PM Pacific Standard Time, faiml@uswest.net writes: << Seems to be still eating, (no weight loss) and his stools seem ok. Doing alot of "lip smacking, gum chewing" behavior. >> Sorry if you've been through this already, but has Patch been checked for Ulcers or Gastritis? What is the nausea medication he's getting? How are the stools? Sometimes a foreign body can duplicate ulcer conditions, has Patch been on any antibiotic medication or steroids for broad-spectrum infection? Try not to worry, we'll figure it out... Wendi 8. Re: FAIML #381; Jan. 30, 2000 (surgery for five-year-old) From: WGHOL@aol.com Date: Mon, 31 Jan 2000 18:43:38 EST << Do you think that it is worthwhile for him to have surgery at his age? I was taking with another ferret owner who says that local breeders don't recommend surgery for 5 year olds because it only gives them a few more months. >> You've definitely been given some "misleading" information here. Ferrets who have adrenal surgery can live a full and happy life, without complications. Depending upon the overall health of the ferret (you'll need a full work up before surgery), and your Vet's experience, it is usually the preferred method of adrenal disease treatment. My girl had her adrenal surgery, and survived for three years afterwards, dying of non-related liver disease just this past August. If you are concerned that his health may be jeopardized, you can opt for medical treatment, including the use of Lupron to shrink the tumor and restrict the adrenal overproduction of hormones. It may also help his urinary difficulties at this point... Dr. Weiss (a notable ferret vet) is using a new treatment of freezing the tumor with a much less invasive surgical procedure. Adrenal disease has made great advances in the past few years, there's now no excuse not to proceed with treatment. Ferrets can live happy lives and get back to "normal" in no time at all. If you'd like more info, please feel free to write, I've had some experience with my own and AD., as well as knowing lots of other adrenal babies with great success stories. Keep me posted, Wendi 9. adrenal surgery for 5 year old From: Moxie Date sent: Mon, 31 Jan 2000 09:45:51 -0500 Hi Gayle, Definitely worth having the surgery. Two of my male ferrets had it at age 5. One lived to 6.5 and died of kidney failure, and the other lived to 7.5 and died of same disease. Both grew their hair back, although the7.5 year old later lost it and had problems with bladder infections. He once blocked and had to be caterized by my vet, but the adrenal surgery definitely added quality time. In fact, the older one had his spleen removed at age 6.5. Ferrets bounce back pretty good from surgery, provided it isn't invasive. Good luck with your guy. Moxie and Chance -- * Page me online through my Personal Communication Center: http://wwp.mirabilis.com/949746 (go there and try it!) or, * Send me E-mail Express directly to my computer screen 949746@pager.mirabilis.com For downloading ICQ at http://www.icq.com/ For adding similar signatures to your e-mail go to: http://www.icq.com/emailsig.html Moxie and Chance 10. pediapred vs. prednisone From: Dave Burket Date sent: Mon, 31 Jan 2000 05:34:32 -0500 Also pediapred does NOT contain alcohol, whereas prednisone and prednisolone DO. Pamela 11. Questions on Lupron From: "Lisa Little" Date sent: Mon, 31 Jan 2000 11:20:36 -0500 .>> The jury is still out on some of these drugs, Lupron is one also, but some believe these only target the brain thus causing "better behavior", some drugs may cause "hair regrowth" and these may convince the owner the ferret is improving...in reality, the tumor may be spreading and becoming more deadly every day<< Hi all, Well Trish posted this and now I'm in a panic because I had decided to have that shot done on my 5 year old next week. Gabby has been diagnosed adrenal and my vet Dr. Sharon Marx of StateCollege PA reccommended that she's a little old and her health may be a bit unstable for her to survive surgery. Gabby just got over a serious bladder infection her blood tests showed possible liver damage at the time but another one is being done this week to see if it was the infection causeing these results. I researched my vet out after using others in the area and have found her very knowlegable about ferrets and very skilled at surgeries on them she does them weekly. I also know that she attends talks on new ferret breakthroughs in medicine and is always discussing my options in a through manner. So I trust her when she suggests Lupron for Gabby over surgery. and when I researched the meds out on the web it sounded ok... not as good as surgery but the next best thing. I guess I want feedback on people who have had this shot done, what the results were and how long it lasted. I'm told 4 to 5 months is the time I can expect the shot to help. Trish if you have time to post to I would be very interested in reading info on people who feel the shot is just working on the brain. Is there a site that has this information? Is it from a vet. I know vets aren't gods and they can be wrong too but alot of them work damn hard at what they do. I just want to hear from people who have used the shot especially ones that did it more then 6 months ago.Thanks alot.:) Lisa and her 9 weasel bears 12. Mitotane From: WGHOL@aol.com Date sent: Mon, 31 Jan 2000 19:24:42 EST In a message dated 1/30/00 8:47:54 PM Pacific Standard Time, Ferrets1st@aol.com writes: << Mitotane (aka: Lysodren) works to actually shrink the adrenal tumor, often preventing it from becoming cancerous. I highly recommend it. >>>>>>>>>>>>>>>>>>> Dr. K. Rosenthal DVM writes in her book about Mitotane: "In my experience, mitotane treatment does not reliably produce resolution of clinical signs in ferrets with adrenocortical tumors; moreover, if clinical signs do resolve, they typically recur when mitotane is discontinued. Be careful when administering mitotane and in warning owners of potential side effects associated with the drug. The primary danger associated with mitotane administration in ferrets is the possible development of severe hypoglycemia after several days of therapy in animals with concurrent insulinoma... Mitotane treatment, although not curative, may be palliative and therefore useful in certain instances. ...treatment of older ferrets that are poor surgical candidates..." I am of the understanding that Mitotane works to destroy the adrenal gland itself, (thus the tumor), anyone else have any info on this? >>>>>>>>>Lupron is one also, but some believe these only target the brain thus causing "better behaviour", some drugs may cause "hair regrowth" and these may convince the owner the ferret is improving...>>>>>>>>>> As a person who has seen great success with Lupron in working to shrink adrenal tumors, I would prefer this medication over the use of Mitotane, if only for the fact that it leaves the adrenal gland in a working state. These are just some personal insights, and I pray every day that extensive research on adrenal disease causes will provide us with a no fuss "cure" if not a preventative... W 13. Several replies From: Ferrets1st@aol.com Date sent: Mon, 31 Jan 2000 15:27:59 EST >> From: Kim Cierpik Khobi…. has a couple spots on her neck and back that look like blood-blister. She has recently stopped eating and is sleeping a lot…. like to know if any of your adrenal babies have had these spots, or stools that are grainy. >> Blood blisters may be topical cycts or cysts/tumors of artery walls (small veins/arteries serve the skin as well) or may be of some other origin. Consult your vet. Grainy stools may well be indicative of ece. Would not consider surgery until poops are normal for few weeks. Try mixing her normal food with water to soften, offer warm with dropper as a "soup". >> From: dagger4u@home.com Well, Patch is sick again… What should I do?? >> Sure sounds like Insulinoma, though could be ulcers, or hairball irritating stomach. Amoxicillin twice daily for one month has been an effective treatment for ulcers. Ask you vet if s/he concurs and will prescribe, or recheck glucose, or both. In some cases, ferrets with ulcers show improvement after only 3 to 5 days on Amoxi. Will also help prevent secondary infection if something else is going on. I am not a vet, so do consult yours, but I do have much experience with sick ferrets and various problems. >> From: "Donald Dittman" If you are having a lot of problems with your insulinomic ferret try extra love and cuddling even if they want left alone. It can't hurt. Laurel >> Great work with Molly Ann. Showing extra attention to sick fuzzies can make an incredible difference, it can even save a life. Check out my website www.ferretsfirst.com, at the top of the main page click ferret care, then on the left margin, click on sick ferrets. That will take you to an article that goes into great detail on caring for sick ferrets, though it would be hard to cover everything in such a short article. >>> From: Gayle Ritzert mrsritz@coast.net My five year old neutered male ferret was diagnosed last week with an adrenal tumor… >>> Whether or not your ferret is a good surgical candidate should be determined by a ferret-knowledgeable vet (not a breeder). I have had surgeries done on 5 year olds and older, recently a surgery on a 6 year old to remove significantly enlarged spleen that was creating other problems, insulinomas, and cysts on liver. If we expected to only get "a few months" as a result, we'd have never done the surgery because it isn't fair for a kid to spend his remaining few months recouperating. We are hoping for years. Where prostrate has enlarged (usually caused by the adrenal tumor) they are more difficult to manage, but there are drugs that may help if for some reason surgery isn't an option for him. Suggest you read article on Adrenal/Insulinoma in March/April 2000 issue of Ferrets magazine…will answer many, many questions you may have. >>> From: Julie Fossa >>> Julie, I am so sorry. I was really rooting for that boy. He put up a good fight. PLEASE send me necropsy results! Remember…the most important thing…Solo knew he was loved. >>> Jerry Murray wrote: I was surprised to read that your ferret is being put on mitotane (Lysodren). Lysodren destroys the cortisol producing cells in the adrenal gland, but in ferrets cortisol is not being overproduced. Remember it is the sex hormones (i.e., estrogens, progesterones, and testosterone) and the androgens (i.e.. DHEA, and Andro.) that are being overproduced by the ferret adrenal glands. Lupron depot (leuprolide acetate) would be a better choice…. If she also has an insulinoma then Lysodren will lower glucose levels, and she will need Pred to raise glucose levels. >>> Considering the number of studies currently underway on the relatively new application of leuprolide acetate for use in ferrets, I am surprised that you assume it would be a better choice. There is obviously a lot to be learned still about this drug's affect on adrenal disease in ferrets. In some ferrets it may be an appropriate option, however, as Dr. Kendrick points out in his article addressing adrenal disease and insulinoma, "treatment of ferrets with adrenal disease and insulinoma, or a combination of both conditions must be patterned to the individual patient". Personally, I have seen significant results in using Lysodren to manage inoperable adrenal tumors. I have used it for many years and on a number of ferrets. I have had several shelter ferrets operated on for adrenal tumors, right side, debulked, not removed entirely, then put on Lysodren. One particular ferret, six months later, underwent surgery again for another reason, the previously debulked adrenal tumor was examined and was found to be half the size it was when the ferret was closed up after the initial surgery. Her hair had regrown and her behavior had also returned to normal. She lived for another 3 years happily, and relatively healthy on Lysodren. Dozens of other ferrets that have been through the shelter have been on Lysodren to manage inoperable adrenal tumors, and only perhaps ten percent showed any problem with the drug, and that was a bit of nausea, decreasing the dosage solved the problem. Only one ferret wasn't helped by Lysodren and died within one month of arriving at the shelter, she was simply too far advanced by the time she came here and had likely had the tumor for years. All others have shown improvement with the drug. Regardless of what textbooks say the drug actually does as far as cortisol levels and sex hormone output, it obviously has some effect on tumors, otherwise symptoms would not subside and tumors would not shrink. It seems vitally important to me that the spread/growth of tumors be stopped because of the high incidence of untreated adrenal tumors metastasizing and creating greater problems, and/or becoming adenocarcinomas. As far as Lysodren lowering blood glucose levels, it would seem that a ferret who had insulinoma should be on Pediapred to manage that condition to begin with. Blood tests before surgeries, in my understanding, are a prerequisite for surgery on ferrets, regardless of their medical history. I am managing several cases at present, of ferrets who have both diseases. They are on Lysodren and Pediapred together, as prescribed by Dr. Kendrick. Their conditions are monitored and they are no less "stable" than those being treated for insulinoma alone (using Pediapred, without Lysodren). >>> From: Amy Claire Dempsey Jack is getting better by the day. Of course, he has already popped a stitch and won't take his antibiotics. He will eat small portions of "duck soup" off a spoon >>> It is vitally important that Jack get his antibiotic. Try mixing with larger portions of "soup" or if Jack will take A/D as a soup it does a better job of masking the taste of medicines. You might want to switch to feeding him out of a large dropper, ferrets almost always consume more this way. They are available in pharmacies for administering meds to children, usually available in 5cc's. If all else fails a compounding pharmacist will be able to "flavor" the Amoxi differently…it's not uncommon for ferrets to object to sweet things like the Amoxi. Compounding pharmacists can flavor anything to taste like anything...chicken, tuna, liver, bubblegum, root beer, peanut butter, banana…and the latest thing is "pounce" flavored Metronidazole (keep your fingers crossed folks, so far it's working). Kisses to all the fuzzies, Trish Director, Ferrets First Rescue & Shelter 14. Addition to previous post... From: Ferrets1st@aol.com Date sent: Tue, 1 Feb 2000 10:05:32 EST I forgot to mention one important point about the little girl operated on twice, her tumor remarkably reduced between surgeries while on Lysodren.... The portion of the adrenal tumor removed during the initial surgery was, of course, sent to a lab for biopsy. Results were the tumor was cancerous. If Lysodren can keep a little girl with cancer going for three years..bouncy and happy as she was, I'd have to say the drug has some merit. There is much controversy over Lysodren, and I have yet to understand why. All drugs have some "down side", you simply have to learn what they are and watch for them and compensate if necessary. Trish Director, Ferrets First Rescue & Shelter 15. BIG's middle name for sale From: Linda Iroff Date sent: Tue, 01 Feb 2000 08:16:09 -0500 Buy Bill Gruber's Middle Name! Win Valuable Prizes! For a limited time only (until Feb 5, 2000) you too can know Bill (BIG) Gruber's mysterious middle name. BIG is the moderator of the Ferret Mailing List and his middle name is one of the most closely guarded secrets on the internet. I assure you that you will be surprised and shocked. To find out his name, send a donation in any amount to the FML Support Our Shelters fund. Checks to S.O.S. should be made out to: Judith White, dba Support Our Shelters and mailed to: Judith White 1236 Belfield Avenue Drexel Hill, PA 19026-4211 As soon as you have put the check in the mail, email me at Linda.Iroff@oberlin.edu and I will email you his middle name. You must have your check in the mail by Feb 5. You must agree not to divulge this name to others to protect its value. The person who makes the largest donation will win a $25 gift certificate to The Ferret Store! In the case of a tie, Judith will place the names in a sleep sack and pull out the winning name. She promises not to peek. (You may request to remain anonymous, just include a note with your check.) BIG himself is also offering a prize, and there will be ferret afghans and soaps awarded at random. Remember this is a limited time offer, so send your check by Feb 5. If you forget to send the check, or if you reveal the name to others, FLO agents are standing by to invade your home, destroy your sofa, poop on your carpets and steal your keys. They may be there already!! Linda Iroff Oberlin OH Linda.Iroff@oberlin.edu ----------------------- End of FAIML #382 -------------------------